药学流动站
2019-04-03
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李俊

单位:药学院

研究方向:抗炎免疫药理、肝脏药理、中药活性成分研究




二级教授,博士生导师。主持9项国家自然科学基金及20项省部级基金项目,获安徽省自然科学一等奖1次,二等奖3次,三等奖3次。培养药学博士后10余人,博士50余人,硕士150余人;国家级规划教材《临床药理学(第4、5、6版)》、《临床药物治疗学》、《临床药物治疗学总论》主编;以第一作者或通讯作者发表SCI收录学术论文 200余篇,获国家发明专利10项。现为中国药学会理事;中国药理学会理事;国家食品药品监督管理局药品、保健品和医疗器械评审专家;安徽省学位委员会委员;中国药理学会药学监护专业委员会副主任委员;中国药理学会临床药理学专业委员会委员;中国药理学会生化药理专业委员会委员;中国药学会中药和天然药物专业委员会委员;教育部高校药学专业指导委员会委员;全国高等学校临床药学专业教材评审委员会副主任委员;安徽省药学会临床药理学专业委员会主任委员,《中国药理学通报》主编。

  

近年代表作

[1]He, Y., D. Feng, M. Li, Y. Gao, T. Ramirez, H. Cao, S.J. Kim, Y. Yang, Y. Cai, C. Ju, H. Wang, J. Li, B. Gao, Hepatic mitochondrial DNA/Toll-like receptor 9/MicroRNA-223 forms a negative feedback loop to limit neutrophil overactivation and acetaminophen hepatotoxicity in mice.Hepatology, 2017. 66(1): 220-234.

[2]Yang, Y., X.Q. Wu, W.X. Li, H.M. Huang, H.D. Li, X.Y. Pan, X.F. Li, C. Huang, X.M. Meng, L. Zhang, X.W. Lv, H. Wang, J. Li, PSTPIP2 connects DNA methylation to macrophage polarization in CCL4-induced mouse model of hepatic fibrosis. Oncogene, 2018.

[3]Peng, Y.Y., Y.H. He, C. Chen, T. Xu, L. Li, M.M. Ni, X.M. Meng, C. Huang, J. Li, NLRC5 regulates cell proliferation, migration and invasion in hepatocellular carcinoma by targeting the Wnt/beta-catenin signaling pathway. Cancer Lett, 2016. 376(1): 10-21.

[4]He, Y., Y.T. Wu, C. Huang, X.M. Meng, T.T. Ma, B.M. Wu, F.Y. Xu, L. Zhang, X.W. Lv, J. Li, Inhibitory effects of long noncoding RNA MEG3 on hepatic stellate cells activation and liver fibrogenesis. Biochim Biophys Acta, 2014. 1842(11): 2204-2215.

[5]Yang, Y., X.X. Chen, W.X. Li, X.Q. Wu, C. Huang, J. Xie, Y.X. Zhao, X.M. Meng, J. Li, EZH2-mediated repression of Dkk1 promotes hepatic stellate cell activation and hepatic fibrosis. J Cell Mol Med, 2017. 21(10): 2317-2328.

  

主持科研项目

[1]国家自然科学基金面上项目,81770609PSTPIP2在肝纤维化形成与逆转中的作用及调控机制研究,2018/01-2021/12,62万元,在研,主持

[2]国家自然科学基金面上项目,81473268NLRC5介导的巨噬细胞极化对肝纤维化形成与逆转的调控及机制研究,2015/01-2018/12100万元,已结题,主持

[3]国家自然科学基金面上项目,81273526NLRC5DNA甲基化修饰调控枯否细胞NF-κB对肝纤维化的影响,2013/01-2016/1270万元,已结题,主持

[4]国家自然科学基金面上项目,81072686TRPM7对肝纤维化大鼠HSC增殖和凋亡的调控作用研究,2011/01-2013/1230万元,已结题,主持

[5]国家自然科学基金面上项目,30973917,基于量效关系分析的复方玉屏风抗炎免疫作用及配伍机制研究,2010/01-2010/128万元,已结题,主持

[6]国家自然科学基金面上项目,30873081,肝纤维化恢复期TRAIL对星状细胞增殖的调控,2009/01-2011/1232万元,已结题,主持

[7]国家自然科学基金面上项目,30672475,肝纤维化恢复期Kupffer细胞对HSC细胞凋亡的调控作用及信号传导机制的研究,2007/01-2007/128万元,已结题,主持

[8]国家自然科学基金面上项目,30572355,枇杷叶三萜酸对慢性支气管炎大鼠肺泡巨噬细胞MAPK通路作用的分子机制研究,2006/01-2008/1228万元,已结题,主持

[9]国家自然科学基金面上项目,30371766,枇杷叶三萜酸对慢性支气管炎的抗炎免疫作用机制,2004/01-2004/127万元,已结题,主持





魏伟

单位:临床药理研究所

研究方向:炎症免疫性疾病的病理机制和药物作用研究



二级教授,药理学博士生导师,国务院政府津贴获得者,安徽医科大学临床药理研究所所长,国家百千万人才工程一二层次。兼任国际基础与临床药理学联合会临床药理学分会理事,中国药理学会副理事长,中国药理学会临床药理学专业委员会名誉主任委员,中国药理学会抗炎免疫药理学专业委员会副主任委员,国家食品药品监督管理局新药审评专家,《中国药理学通报》主编,抗炎免疫药物教育部重点实验室主任,安徽省“115”产业创新团队带头人等。承担了国家863项目、国家自然科学基金重点项目等多项课题研究,发表学术论文200多篇,获得安徽省科学技术奖一等奖1项、省级科学技术奖二等奖2项和4项国家发明专利。


近年代表作

[1]Shu JL,Zhang XZ,Han L,Zhang F,Wu YJ,Tang XY,Wang C,Tai Y,Wang QT,Chen JY,Chang Y,Wu HX,Zhang LL,Wei W. Paeoniflorin-6'-O-benzene sulfonate alleviates collagen-induced arthritis in mice by downregulating BAFF-TRAF2-NF-κB signaling: comparison with biological agents. Acta Pharmacol Sin.2018 Nov 16. doi: 10.1038/s41401-018-0169-5. [Epub ahead of print]。

[2]Zhao M,Zhou P,Yu J,James A,Xiao F,Wang C,Wei W. The tissue distribution and excretion study of paeoniflorin-6'-O-benzene sulfonate (CP-25) in rats. Inflammopharmacology.2018 Mar 9. doi: 10.1007/s10787-018-0463-3.

[3]Wu YJ,Wang C,Wei W. The effects of DMARDs on the expression and function of P-gp, MRPs, BCRP in the treatment of autoimmune diseases. Biomed Pharmacother.2018 Sep;105:870-878. doi: 10.1016/j.biopha.2018.06.015。

[4]Wu YJ,Zhao MY,Wang J,Tang H,Wang B,Xiao F,Liu LH,Zhang YF,Zhou AW,Wang C,Wei W. Absorption and efflux characteristics of CP-25 in plasma and peripheral blood mononuclear cells of rats by UPLC-MS/MS. Biomed Pharmacother.2018 Dec;108:1651-1657. doi: 10.1016/j.biopha.2018.09.156.

[5]Wu YJ,Chen HS,Chen WS,Dong J,Dong XJ,Dai X,Huang Q,Wei W. CP-25 Attenuates the Activation of CD4+T Cells Stimulated with Immunoglobulin D in Human. Front Pharmacol.2018 Jan 23;9:4.

[6]Tu J,Hong W,Zhang P,Wang X,Körner H,Wei W. Ontology and Function of Fibroblast-Like and Macrophage-Like Synoviocytes: How Do They Talk to Each Other and Can They Be Targeted for Rheumatoid Arthritis Therapy? Front Immunol.2018 Jun 26;9:1467. doi: 10.3389/fimmu.2018.01467.

[7]Tu J,Tian G,Cheung HH,Wei W,Lee TL. Gas5 is an essential lncRNA regulator for self-renewal and pluripotency of mouse embryonic stem cells and induced pluripotent stem cells. Stem Cell Res Ther.2018 Mar 21;9(1):71. doi: 10.1186/s13287-018-0813-5.

[8]Tai Y,Wang Q,Korner H,Zhang L,Wei W. Molecular Mechanisms of T Cells Activation by Dendritic Cells in Autoimmune Diseases. Front Pharmacol.2018 Jun 26;9:642. doi: 10.3389/fphar.2018.00642.

[9]Chen J,Wang Y,Wu H,Yan S,Chang Y,Wei W. A Modified Compound From Paeoniflorin, CP-25, Suppressed Immune Responses and Synovium Inflammation in Collagen-Induced Arthritis Mice. Front Pharmacol.2018 Jun 7;9:563. doi: 10.3389/fphar.2018.00563.

[10]Chen J,Si M,Wang Y,Liu L,Zhang Y,Zhou A,Wei W.Ginsenoside metabolite compound K exerts anti-inflammatory and analgesic effects via downregulating COX2. Inflammopharmacology.2018 Jun 26. doi: 10.1007/s10787-018-0504-y. [Epub ahead of print]

[11]Chen X,Wu H,Wei W. Advances in the diagnosis and treatment of Sjogren's syndrome. Clin Rheumatol.2018 Jul;37(7):1743-1749. doi: 10.1007/s10067-018-4153-8. Epub 2018 May 26.

[12]Zhang L,Yu J,Wei W. Advance in Targeted Immunotherapy for Graft-Versus-Host Disease. Front Immunol.2018 May 16;9:1087. doi: 10.3389/fimmu.2018.01087.

[13]Zhang L,Huang D,Shao D,Liu H,Zhou Q,Gui S,Wei W,Wang Y. Fenretinide inhibits the proliferation and migration of human liver cancer HepG2 cells by downregulating the activation of myosin light chain kinase through the p38‑MAPK signaling pathway. Oncol Rep.2018 Jul;40(1):518-526. doi: 10.3892/or.2018.6436. Epub 2018 May 16.

[14]Gu F,Xu S,Zhang P,Chen X,Wu Y,Wang C,Gao M,Si M,Wang X,Heinrich K,Wu H,Wei W. CP-25 Alleviates Experimental Sjögren's Syndrome Features in NOD/Ltj Mice and Modulates T Lymphocyte Subsets. Basic Clin Pharmacol Toxicol.2018 Apr 17. doi: 10.1111/bcpt.13025. [Epub ahead of print]

[15]Wang Y,Han CC,Cui D,Luo TT,Li Y,Zhang Y,Ma Y,Wei W. Correction to: Immunomodulatory Effects of CP-25 on Splenic T Cells of Rats with Adjuvant Arthritis. Inflammation.2018 Jun;41(3):1064. doi: 10.1007/s10753-018-0770-2.

[16]Tang X,Zhang L,Wei W. Roles of TRAFs in NF-κB signaling pathways mediated by BAFF. Immunol Lett.2018 Apr;196:113-118. doi: 10.1016/j.imlet.2018.01.010. Epub 2018 Feb 20.

[17]Wang YY,Tang LQ,Wei W. Berberine attenuates podocytes injury caused by exosomes derived from high glucose-induced mesangial cells through TGFβ1-PI3K/AKT pathway. Eur J Pharmacol.2018 Apr 5;824:185-192. doi: 10.1016/j.ejphar.2018.01.034. Epub 2018 Feb 22.

[18]Wang X,Chen X,Huang W,Zhang P,Guo Y,Körner H,Wu H,Wei W. Losartan suppresses the inflammatory response in collagen-induced arthritis by inhibiting the MAPK and NF-κB pathways in B and T cells. Inflammopharmacology.2018 Nov 13. doi: 10.1007/s10787-018-0545-2. [Epub ahead of print]

[19]Wu H,Chen J,Wang C,Liu L,Wu Y,Zhang Y,Zhou A,Zhang L,Wei W. β2-adrenoceptor signaling reduction is involved in the inflammatory response of fibroblast-like synoviocytes from adjuvant-induced arthritic rats. Inflammopharmacology.2018 Apr 19. doi: 10.1007/s10787-018-0477-x. [Epub ahead of print]

[20]Xiao F,Zhang F,Zhang LL,Wei W. A randomized phase I study to evaluate the safety, tolerability, pharmacokinetics and food-effect of Iguratimod in healthy adult volunteers. Eur J Clin Pharmacol.2018 Jan;74(1):69-77. doi: 10.1007/s00228-017-2342-z. Epub 2017 Oct 19.

[21]Zhang LL, Wei W, Xiao F, Xu JH, Bao CD, Ni LQ, Li XF. Randomized, double -blind, multi -center, controlled clinical trial of chicken type II collagen in rheumatoid arthritis. Arthritis Rheum. 2008; 59(7): 905-910.

[22]Chang Y, Zhang L, Wang C, Jia XY,Wei W. Paeoniflorin inhibits function of synoviocytes pretreated by rIL-1αand regulates EP4 receptor expression.J Ethnopharmacol. 2011;137(3):1275-82.

[23]Jia XY, Chang Y, Sun XJ, Wu HX, Wang C, Xu HM, Zhang L, Zhang LL, Zheng YQ, Song LH,Wei W. Total glucosides of paeony inhibit the proliferation of fibroblast-like synoviocytes through the regulation of G proteins in rats with collagen-induced arthritis. Int Immunopharmacol. 2014;18(1):1-6.

[24]Wang QT, Zhang LL, Wu HX, Wei W. The expression change of β-arrestins in fibroblast-like synoviocytes from rats with collagen-induced arthritis and the effect of total glucosides of paeony.J Ethnopharmacol. 2011; 133: 511-6.

[25]Chen JY, Wu HX, Chen Y, Zhang LL, Wang QT, Sun WY, Wei W. Paeoniflorin inhibits proliferation of fibroblast-like synoviocytes through suppressing G-protein-coupled receptor kinase 2. Planta Medica, 2012; 78(7):665-71

 

主持科研项目

[1]G蛋白偶联受体激酶调控胶原性关节炎滑膜细胞G蛋白偶联信号及白芍总苷的作用,305723562006-200826万,国家自然科学基金面上项目

[2]B淋巴细胞刺激因子与其受体介导实验性关节炎的病理机制及TACI-Ig的治疗作用,309735432010-201236万元,国家自然科学基金面上项目

[3]B淋巴细胞刺激因子受体BAFF-RBCMATACI介导信号和相互关系在胶原性关节炎发病中作用及受体抑制剂对其的影响,811730752012-201550万元,国家自然科学基金面上项目

[4]新型活性单体芍药苷-6--苯磺酸酯在类风湿关节炎免疫应答与炎症中的调控作用,813300812014-2018290万元,国家自然科学基金重点项目

[5]血管紧张素受体及其信号对类风湿关节炎异常活化的巨噬细胞样滑膜细胞的调控作用,816734442017-202070万元,国家自然科学基金面上项目




陈飞虎

单位:药学院

研究方向:抗炎免疫药理学、分子药理学、临床药理学





二级教授,博士生导师,安徽医科大学科技处处长,全国高校首批黄大年式教师团队-药学教师团队负责人,安徽省学术与技术带头人,安徽省高校教学名师,安徽省政协委员,安徽省药理学会理事长。研究方向为抗炎免疫药理学、分子药理学、临床药理学。近年来承担国家自然科学基金5项、国家十一五计划科技重大专项“重大新药创制”专项项目1项、国家十二五计划科技重大专项“重大新药创制”平台项目1项、国家中医药行业专项1项,发表学术论文300余篇,以第一完成人申请国家专利9项及美国专利、欧洲专利各1项。

  

近年代表作

[1]Xia Li, Fan Rong Wu, Rui Sheng Xu, Wei Hu, Dong Lin Jiang, Cheng Ji,Fei Hu Chen , Feng Lai Yuan. Acid-sensing ion channel1a-mediated calcium influx regulates apoptosis of endplate chondrocytes in intervertebral discs. Expert Opin. Ther. Targets. 2014 Jan;18(1):1-14Q1区,影响因子5.139

[2]Jin-Fang Ge, Wen-Chao Gao, Wen-Ming Cheng, Wei-Li Lu, Jie Tang, Lei Peng, Ning Lin, Fei-Hu Chen. Orcinol glucoside produces antidepressant effects by blocking the behavioural and neuronal deficits caused by chronic stress. European Neuropsychopharmacology. 2014, 24:172-180.Q1区,影响因子5.395

[3]Ren-Peng Zhou, Bei-Bei Dai, Ya-Ya Xie, Xiao-Shan Wu, Zhi-Sen Wang, Yue Li, Zhi-Qiang Wang, Sheng-Qin Zu, Jin-Fang Ge, Fei-Hu Chen. Interleukin-1βand tumor necrosis factor-αaugment acidosis-induced rat articular chondrocyte apoptosis via nuclear factor-kappaB-dependent upregulation of ASIC1a channel. BBA - Molecular Basis of Disease. (2017) doi: 10.1016/j.bbadis.2017.10.004. Epub 2017 Oct 3.Q1区,影响因子:5.476

  

主持科研项目

[1]内抑素(Endostatin)对大鼠佐剂性关节炎滑膜细胞作用的分子机制(项目批准号:30572196),国家自然科学基金,2006-200828万元,项目负责人

[2]治疗肝纤维化新药鬼针草总黄酮胶囊的临床前研究(项目批准号:2009ZX09103-386),国家重大新药创制科技重大专项,2009-2010150万元,项目负责人

[3]类风湿关节炎关节软骨细胞酸敏感离子通道的药理学特性研究(项目批准号:30873080),国家自然科学基金,2009-201130万元,项目负责人

[4]4、、企业创新药物孵化基地建设,(项目批准号:2011ZX09401-021),国家重大新药创制科技重大专项平台建设,2012-2014800万元,子项目负责人

[5]ASICs的表达与开放在佐剂性关节炎(AA)大鼠关节软骨细胞凋亡中的作用及其机制(项目批准号:81271749),国家自然科学基金,2013-201670万元,项目负责人

[6]丹皮品种选育及种植质量控制技术研究(项目批准号:201507002-1-05),国家中医药行业专项,2015-2018107万元,项目负责人

[7]ASlC1a介导的自噬对佐剂性关节炎(AA)大鼠关节软骨细胞的作用及其机制,(项目批准号:81672127),国家自然科学基金,2017-201825万元,项目负责人

[8]雌激素及其受体对ASIC1a介导的关节软骨细胞凋亡的保护作用及其机制,(项目批准号:81873986),国家自然科学基金,2019-202257万元,项目负责人

[9]诱导肿瘤细胞分化一类新药4-氨基-2-三氟甲基苯基维甲酸酯治疗白血病研究,(项目批准号:17030801020),安徽省科技重大专项,2019-2022120万元,项目负责人

[10]基于靶标的新药发现团队,安徽省高校领军人才团队,2019-2021400万元,项目负责人 

  

专利或获奖

[1]Feihu Chen. Retinoid derivative and pharmaceutical composition and use thereofUS 8,110,703B2The united states patent trademark office2012.02

[2]鬼针草生药学鉴定、有效部位的提取分离纯化及抗肝纤维化研究,安徽省科技进步奖,三等奖,2014(排名第一)。

  





沈玉先

单位:基础医学院

研究方向:功能蛋白与药物作用靶点




二级教授,博士生导师,现为安徽医科大学基础医学院院长、生物药物研究所所长。教育部“新世纪优秀人才”入选者,安徽省领军人才团队带头人、安徽省学术技术带头人,安徽省高校拔尖人才。承担国家自然科学基金委重大研究计划(培育项目)1项、面上项目6项,其他省部级课题8项。以第一作者或通讯作者发表SCI论文40余篇,论文主要发表在Autophagy、J Pineal Res、Free Radical Bio Med、J Cereb Blood Flow Metab、J Neuroinflammation等高影响力的SCI源期刊上。获省科学技术奖一等奖1项(第一完成人)、二等奖3项(分别为第二、三、四完成人)。

  

近年代表作

[1]Xu SC, Di ZM, He YF, Wang RJ, Ma YY, Sun R,Li J, Wang T, Shen YJ, Fang SY, Feng LJ*, Shen YX*, Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against Aβ toxicity via attenuating Aβ-induced endoplasmic reticulum stress. JNeuroinflamm 2019, 16(1). (IF=5.785)

[2]ZhengH, YuWM,ShenJH,KangSM,HambardzumyanD,LiJ,ShenYX,KenneyA,Chen J,QuCK, Mitochondrial oxidation of the carbohydrate fuel is required for neural precursor/stem cellfunction and postnatal cerebellar development. Sci Adv 2018, 10; 4 (10):eaat2681.(IF=11.511)

[3]Feng LJ, Zhang J, Zhu N, Ding Q, Zhang XJ, Yu JS, Qiang WM, Zhang ZT, Ma YY, Huang DK, Shen YJ, Fang SY, Yu YF, Wang HP*, Shen YX*. Ubiquitin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z variant/alpha-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy.Autophagy 2017,13(4):686-702. (IF=12.042)

[4]Zhang WP, Chen LH, Feng H, Wang W, Cai Y , Qi F, Tao XF, Liu J, Shen YJ, Ren XF, Chen X , Xu JM*, Shen YX*. Rifampicin-induced injury in HepG2 cells is alleviated by TUDCA via increasing bile acid transporters expression and enhancing the Nrf2-mediated adaptive response. Free Radical Bio Med 2017, 112:24-35. (IF=6.02)

[5]Song MM*, Xu HL, Liang JX, Xiang HH, Liu R, Shen YX*. Lactoferrin modified graphene oxide iron oxide nanocomposite for glioma-targeted drug delivery. Mat Sci Eng C-Mater 2017, 1;77:904-911.(IF=5.08)

[6]Wu F, Wang P, Shen YX, Nobuo N. Noda, Zhang H. Small differences make a big impact: Structural insights into the differential function of the 2 Atg8 homologs in C. elegans.Autophagy 2016, 12(3):606-607.(IF=12.042)

[7]Liu J, Tao X, Zhang J, Wang P, Sha M, Ma Y, Geng X, Feng L, Shen Y , Yu Y, Wang S, Fang S, Shen Y*. Small ubiquitin-related modifier 1 is involved in hepatocellular carcinoma progression via mediating p65 nuclear translocation. Oncotarget. 2016; DOI: 10.18632/oncotarget.8066. (IF=6.359)

[8]Wu F, Watanabe Y, Guo XY, Qi X, Wang P, Zhao HY, Wang Z, Fujioka Y, Zhang H, Ren JQ, Fang TC,Shen YX, Feng W, Hu JJ, Noda N*, and Zhang H*. Structural basis of the differential function of the two C. elegans Atg8 homologs,LGG-1 and LGG-2, in autophagy. Mol Cell 2015, 17;60(6):914-929.(IF=15.28)

[9]Chen LJ, Feng LJ, Wang X, Du J, Chen Y, Yang W, Zhou CY, Cheng L, Shen YJ, Fang SY, Li J, Shen YX*. Mesencephalic astrocyte-derived neurotrophic factor is involved in inflammation by negatively regulating the NF-kB pathway. Sci Rep 2015, 5:8133. (IF=5.578)

[10]Shen YJ, Sun AM, Wang YH, Cha DQ, Wang HP, Wang F,C Feng LJ, Fang SY*, Shen YX*. Upregulation of mesencephalic astrocyte-derived neurotrophic factor (MANF) in glial cells is associated with ischemia-induced glial activation. J Neuroinflamm 2012, 9(1):254. (IF=5.785).

[11]Shen YX*, Sun AM, Fang S, Feng LJ, Li Q, Hou HL, Liu C, Wang HP,Shen JL, Luo J, Zhou JN*. Hrd1 Facilitates Tau Degradation and Promotes Neuron Survival. Curr Mol Med 2012, 12 (2): 138-152 (IF=5.212).

[12]Yu YQ, Liu LC, Wang FC, Liang Y, Cha DQ, Zhang JJ, Shen YJ, Wang HP, Fang S, Shen YX*. Induction profile of MANF/ARMET by cerebral ischemia and its implication for neuron protection. J Cereb Blood Flow Metab 2010, 30:79-91 (IF=6.045).

[13]Shen YX*, Xu SY, Wei W, et al. The protective effects of melatonin from oxidative damage induced by amyloid beta-peptide 25-35 in middle-aged rats. J Pineal Res 2002, 32: 85-89. (IF=11.613)

[14]Shen YX*, Xu SY, Wei W, et al. Melatonin blocks rat hippocampal neuronal apoptosis induced by amyloid beta-peptide 25-35. J Pineal Res 2002, 32: 163-167. (IF=11.613)

[15]Shen YX*,Xu SY,Wei W, et al. Melatonin reduces memory changes and neural oxidation damage in mice treated with D-galactose. J Pineal Res 2002, 32: 173-178. (IF=11.613)

  

  

主持科研项目

[1]国家自然科学基金面上项目:肝细胞源性神经营养因子MANF经外泌体靶向HSCs的抗肝纤维化作用及机制研究,编号816734382017.1-2020.12),60

[2]国家自然科学基金面上项目:新型神经营养因子MANF 对肝细胞癌的抑制作用及其机制研究,编号813725762014.1-2017.12),85

[3]国家自然科学基金重大研究计划(培育项目):内质网应激在乙型肝炎-肝硬化-肝癌转化过程中的调节机制及相关药物作用靶分子筛选,编号911297292012.1-2014.12),80

[4]国家自然科学基金面上项目:炎症诱导的ARMET转录激活及其对NF-κB信号通路的调节机制,编号811730742012.1-2015.12),63

[5]国家自然科学基金面上项目:泛素连接酶Hrd1介导的tau蛋白降解,编号307725572008.1-2010.12),34

[6]国家自然科学基金面上项目:泛素连接酶hHrd1a1-抗胰蛋白酶Z变异型的降解的调控机制,编号30572219(2006.1-2008.12)27

  


 

杨雁

单位:基础医学院

研究方向:免疫药理学



教授,博士生导师,享受国务院特殊津贴,安徽省学术和技术带头人。曾赴日本关西医科大学和澳大利亚昆士兰大学留学。主持四项国家自然科学基金面上项目等课题,发表论文百余篇,参编出版五著作,获两项国家专利。获安徽省自然科学壹等奖、省“知识型女职工”荣誉称号、省青年科技奖、省多媒体教学课件二等奖、省优秀硕士学位论文(导师)、安医大2014年度最具影响力十佳论文、连续两届安医大优秀博士学位论文(导师)。任中国药理学会抗炎免疫药理专业委员会委员,省院士专家联谊会理事,省药理学会常务理事、安医大学学报编委、国家自然科学基金同行评审专家等。


近年代表作

[1]Wu C, Chen W, Fang M, Boye A, Tao X, Xu Y Hou S,Yang Y*. Compound Astragalus and Salvia miltiorrhiza extract inhibits hepatocellular carcinoma progression via miR-145/miR-21 mediated Smad3 phosphorylation. J Ethnopharmacol, 2019, 231:98-112,SCIIF:3.115,JCR Q1.

[2]Yang JJ, She Q,Yang Y*, Tao H, Li J*. DNMT1 controls LncRNA H19/ERK signal pathway in hepatic stellate cell activation and fibrosis. Toxicology letters, 2018,295:325-34,SCIIF:3.166,JCR Q1.

[3]Wang JY, Fang M, Boye A, Wu C, Wu JJ, Ma Y, Hou S, Kan Y,Yang Y*. Interaction of microRNA-21/145 and Smad3 domain-specific phosphorylation in hepatocellular carcinoma. Oncotarget, 2017, 8:84958-73,SCIIF:5.168,JCR Q1.

[4]Rui W, Zou Y, Lee J, Nambiar SM,Lin J, Zhang L,Yang Y*, Dai G*. Nuclear Factor Erythroid 2-Related Factor 2 Deficiency Results in Amplification of the Liver Fat-Lowering Effect of Estrogen. J Pharmacol Exp Ther, 2016, 358:14-21,SCIIF:3.867,JCR Q1.

[5]Boye A,ZouY,Yang Y*.Metabolic derivatives of alcohol and the molecular culprits of fibro-hepatocarcinogenesis:Allies or enemies?.World J Gastroenterol,2016,22:50-71,SCIIF:3.363,JCR Q2.

[6]Boye A, Kan H, Wu C, Jiang Y, Yang X, He S*,Yang Y*. MAPK inhibitors differently modulate TGF-β/Smad signaling in HepG2 cells. Tumor Biol,2015,36:3643-51,SCIIF:3.611,JCR Q2.

[7]Jiang Y, Wu C, Boye A, Wu J, Wang J, Yang X,Yang Y*. MAPK inhibitors modulate Smad2/3/4 complex cyto-nuclear translocation in myofibroblasts via Imp7/8 mediation. Mol Cell Biochem, 2015, 406:255-62.SCIIF:2.613.

[8]Boye A, Wu C, Jiang Y, Wang J, Wu J, Yang X,Yang Y*. Compound Astragalus and Salvia miltiorrhiza extracts modulate MAPK-regulated TGF-β/Smad signaling in hepatocellular carcinoma by multi-target mechanism. J Ethnopharmacol, 2015, 169:219-28,SCIIF:3.055,JCR Q1.

[9]Hu M, Zou Y, Nambiar SM, Lee J,Yang Y*, Dai G*.Keap1 modulates the redox cycle and hepatocyte cell cycle in regenerating liver. Cell Cycle 2014;13:2349-58.SCIIF:4.565,JCR Q2.

[10]Boye A,Yang Y*. Hepatic microRNAorchestra: a new diagnostic, prognostic and theranostic tool forhepatocarcinogenesis. Mini Reviews in Medicinal Chemistry, 2014, 14:837-52.SCIIF:2.903,JCR Q2.

[11]Wu C, Jiang J, Boye A, Jiang Y,YangY*. Compound Astragalus and Salvia miltiorrhiza extract suppresses rabbits' hypertrophicscar by modulating the TGF-β/Smad signal. Dermatology, 2014, 229:363-8.SCIIF:1.569, JCR Q2.

[12]Hu X, Rui W, Wu C, He S, Jiang J, Zhang X*,Yang Y*. Compound Astragalus and Salvia miltiorrhiza extracts suppress hepatocarcinogenesis bymodulating transforming growth factor-β/Smad signaling.J Gastroenterol Hepatol, 2014, 29:1284-91.SCIIF:3.504, JCR Q2.

[13]Rui W, Xie L, Liu X, He S, Wu C, Zhang X, Zhang L*,Yang Y*. Compound Astragalus and Salvia miltiorrhiza extract suppresses hepatocellular carcinoma progression by inhibiting fibrosis and PAI-1 mRNA transcription. J Ethnopharmacol,2014, 151:198-209.SCIIF:3.055, JCR Q1.

[14]He S,Yang Y*, Liu X, Huang W, Zhang X, Yang S, Zhang X. Compound Astragalus and Salvia miltiorrhiza extract inhibits cell proliferation, invasion and collagen synthesis in keloid fibroblasts by mediating transforming growth factor-beta/Smad pathway.Br J Dermatol, 2012, 166: 564-74. SCIIF:3.759,JCR Q1.

[15]He S, Liu X,Yang Y*, Huang W, Xu S, Yang S, Zhang X, Roberts MS. Mechanisms of transforming growth factor beta/Smad signalling mediated by mitogen-activated protein kinase pathways in keloid fibroblasts.Br J Dermatol, 2010, 162: 538-46. SCIIF:4.353, JCR Q1.

 

主持科研项目

[1]Nrf2Smad3在肝纤维化-肝癌发展进程中的交互作用机制及黄芪甲苷的干预(81874354)国家自然基金面上项目2019-01-2022.12, 56

[2]Smad3 C末端和连接区磷酸化位点突变对肝纤维化-肝癌发展进程的调控及丹酚酸B的干预(81573652)国家自然基金面上项目2016-01-2019.12, 57

[3]miR-145miR-21TGF-β/Smad信号通路的相互作用在复方芪参提取物抗肝癌机制中的研究(81374012)国家自然基金面上项目2014-01-2017.12,68

[4]复方芪参提取物抗肝纤维化-肝癌的TGF-β/Smad信号转导及MAPK通路调控机制(81073098)国家自然基金面上项目2011-01-2013.12,33

[5]MAPK通路调控下经Smad2/3连接区信号途径的瘢痕疙瘩分子发病机理(KJ2008A30ZC)安徽省教育厅自然科学基金(重点项目)资助2008.1-2010.12,

[6]复方黄芪提取物抗肝纤维化作用的TGF-β信号转导机制(2008Z027)安徽省人才基金2008.01-2010.12, 4