叶冬青

单位：公共卫生学院

研究方向：分子流行病学，传染病流行病学，慢性病流行病学等

二级教授，博士生导师。英国皇家内科医学院公共卫生学院院士（FTD）；从事流行病与卫生统计学教学和科研工作，研究方向为分子流行病学，传染病流行病学，慢性病流行病学等。享受国务院特殊津贴；卫生部有突出贡献中青年专家；获吴阶平-保罗•杨森医学医药奖。现任安徽医科大学临床医学院常务副院长、中华预防医学会流行病学分会常委、中华临床流行病学学会委员、亚太医学生物免疫学会理事会常务理事、基础免疫分会常务委员、安徽省免疫学会常务理事、安徽省预防医学会流行病学专业委员会主任委员、《中华疾病控制杂志》主编、《中华流行病学杂志》等杂志编委。

近年代表作

[1]Evidence of epistatic interaction between DPP4 and CCR6 in patients with rheumatoid arthritis.,Rheumatology (Oxford),2016;55(12):2230-2236.

[2]Subclinical atherosclerosis in patients with systemic lupus erythematosus: A systemic review and meta-analysis.,Autoimmun Rev,2016;15(1):22-37.

[3]Comparative effectiveness and tolerance of treatments for Helicobacter pylori: systematic review and network meta-analysis.,BMJ,2015;351,h4052.

[4]Emerging role of long noncoding RNAs in autoimmune diseases.,Autoimmun Rev,2015;14,9,798-805.

[5]IL-17A-producing CD8(+)T cells as therapeutic targets in autoimmunity.,Expert Opin Ther Targets,2015;19,5,651-61.

[6]microRNAs function in CD8+T cell biology.,J Leukoc Biol,2015;97,3,487-97.

[7]Long noncoding RNAs: novel insights into gastric cancer.,Cancer Lett,2015;356,2 Pt B,357-66.

[8]Tc17 Cells in Immunity and Systemic Autoimmunity.,Int Rev Immunol,2015;34,4,318-31.

[9]Two follicle-stimulating hormone receptor polymorphisms and polycystic ovary syndrome risk: a meta-analysis.,Eur J Obstet Gynecol Reprod Biol,2014;182,27-32.

[10]Targeting T-helper 9 cells and interleukin-9 in autoimmune diseases.,Cytokine Growth Factor Rev,2013;24,6,515-22.

[11]The risk factors of avascular necrosis in patients with systemic lupus erythematosus: a meta-analysis.,Inflammation,2014;37,5,1852-64.

[12]Therapeutic potential of STAT4 in autoimmunity.,Expert Opin Ther Targets,2014;18,8,945-60.

[13]Emerging role of SIGIRR rs7396562(T/G) polymorphism in systemic lupus erythematosus in a Chinese population.,Inflammation,2014;37,5,1847-51.

[14]Association study of interleukin-19 rs2243188 polymorphism with systemic lupus erythematosus in a Chinese population.,Autoimmunity,2014;47,6,378-82.

[15]Therapeutic potential of tyrosine kinase 2 in autoimmunity.,Expert Opin Ther Targets,2014;18,5,571-80.

[16]SOCS signaling in autoimmune diseases: molecular mechanisms and therapeutic implications.,Eur J Immunol,2015;44,5,1265-75.

主持科研项目

[1]国家自然科学基金,Toll样受体9在系统性红斑狼疮发病中的分子机制研究,项目编号30771848,起止时间2008-01~ 2010-12,30万元

[2]国家自然科学基金重点项目,系统性红斑狼疮遗传易感性的流行病学研究,项目编号30830089,起止时间2009-011~ 2012-12,155万元

[3]国家自然科学基金,MicoRNA与系统性红斑狼疮发病相关性的分子流行病学研究,项目编号81172764,起止时间2012-01~ 2015-12,54万元

[4]国家自然科学基金,低氧诱导因子1α与系统性红斑狼疮的相关性研究,项目编号81271759,起止时间2013-01~2016-12,70万元

[5]国家自然科学基金,基于动态队列开展TTP参与系统性红斑狼疮发病的分子流行病学研究,项目编号81473058,起止时间2015-01~ 2018-12,85万元

[6]国家自然科学基金国际合作项目,寻常型天疱疮的遗传学基础研究,项目编号81461148002,起止时间2014-10~ 2017-09,182万元

[7]7.2016年国家自然科学基金,CircRNA与系统性红斑狼疮发病相关性的分子流行病学研究,项目编号81673258,起止时间2017-01~ 2020-12,65万元

陶芳标

单位：卫生管理学院

研究方向：青少年发育与健康、生命早期环境暴露母婴健康效

二级教授，博士生导师。现为人口健康与优生安徽省重点实验室主任，安徽医科大学卫生管理学院院长。研究方向为青少年发育与健康、生命早期环境暴露母婴健康效应。主持或承担国家科技支撑计划重大项目、国家863目标导向性项目、国家重大研究计划、国家自然科学基金重点项目等多层面的科研课题12项，建立了中国安徽出生队列和中国青少年行为与健康监测协作研究网络，研制4项国家卫生标准颁布实施。主编国家规划教材和学术专著6部，其中《出生缺陷环境病因及其可控性研究》获得国家“三个一百”原创出版工程奖。受聘中华预防医学会儿少卫生分会副主任委员、《中国学校卫生》杂志总编辑、《中华预防医学杂志》副总编辑。先后被评为“全国先进工作者”、“全国优秀科技工作者”、“预防医学突出贡献奖”。

近年代表作

[1]Qi J, Lai Y , Liang C, Yan S, Huang K , Pan W, Feng L, Jiang L , Zhu P , Hao J, Tong S , Tao F*. Prenatal thallium exposure and poor growth in early childhood: A prospective birth cohort study. Environ Int, 2019,123:224-230.

[2]Wan Y, Chen R, Ma S, McFeeters D, Sun Y, Hao J, Tao F*. Associations of adverse childhood experiences and social support with self-injurious behaviour and suicidality in adolescents. Br J Psychiatry, 2019,214(3):146-152.

[3]Liang CM, Wu XY, Huang K, Yan SQ, Li ZJ, Xia X, Pan WJ, Sheng J, Tao YR, Xiang HY, Hao JH,Wang QN, Tao FB*, Tong SL*. Trace element profiles in pregnant women's sera and umbilical cord sera and influencing factors: Repeated measurements. Chemosphere,2019,218:869-878.

[4]Li ZJ, Liang CM, Xia X, Huang K, Yan SQ, Tao RW, Pan WJ, Sheng J, Tao YR, Xiang HY, Hao JH,Wang QN, Tong SL*, Tao FB*. Association between maternal and umbilical cord serum cobalt concentration during pregnancy and the risk of preterm birth: The Ma'anshan birth cohort (MABC) study. Chemosphere, 2019,218:487-492.

[5]Zhu YD, Zhu BB, Gao H, Huang K, Xu YY, Yan SQ，Zhou SS,Cai XX, Zhang QF, Qi J, Jin ZX, Sheng J, Pan WJ, Hao JH, Zhu P , Tao FB*. Repeated measures of prenatal phthalate exposure and maternal hemoglobin concentration trends: The Ma'anshan birth cohort (MABC) study. Environ Pollut, 2018,242(Pt B):1033-1041.

[6]Gao H, Zhu BB, Tao XY, Zhu YD, Tao XG , Tao FB*. Temporal variability of cumulative risk assessment on phthalates in Chinese pregnant women: repeated measurement analysis. Environ Sci Technol, 2018,52(11):6585-6591.

[7]Gao H, Zhu YD, Xu YY, Zhang YW, Yao HY, Sheng J, Jin ZX, Ren LL, Huang K, Hao JH, Tao FB*. Season-dependent concentrations of urinary phthalate metabolites among Chinese pregnant women: Repeated measures analysis. Environ Int, 2017, 104:110-117.

[8]Gao H, Xu YY, Huang K, Ge X, Zhang YW, Yao HY, Xu YQ, Yan SQ, Jin ZX, Sheng J, Zhu P, Hao JH, Tao FB*. Cumulative risk assessment of phthalates associated with birth outcomes in pregnant Chinese women: A prospective cohort study. Environ Pollut,2017, 222:549-556.

[9]陶芳标*.学校—学生—学业联动是打好儿童青少年近视防控攻坚战的基石. 中国学校卫生，2019,40(1): 4(1):3-6..

[10]陶芳标*.儿童健康促进应始于生命的孕育阶段.中华预防医学杂志, 51(9):777-780, 2017.

主持科项目

[1]陶芳标. 孕期PAEs暴露与学龄前儿童认知损伤的出生队列研究. 国家自然科学基金重点项目（（81330068），2014—2018

[2]陶芳标. 基于初级卫生保健系统的围生期抑郁的筛查与管理. 国家自然科学基金国际合作与交流项目（81761128034），2018—2022

[3]陶芳标（PI）. 中国人群辅助生殖人口及子代队列建立与应用基础研究—环境-基因交互作用对子代结局的影响. 国家重点研发计划（2016YFC1000204-2），2016—2021

[4]陶芳标（组长）. 不孕不育人群环境与遗传致病因子鉴定及交互作用研究. 国家重点研发计划（2018YFC1004200），2018—2021

[5]陶芳标. 孕期过度增重与儿童内外化行为和神经发育障碍关联的出生队列研究. 国家自然科学基金面上项目（81573168）.2016—2019

二级教授，博士生导师，公共卫生学院副院长，环境毒理学安徽省高校重点实验室主任，国务院政府特殊津贴获得者，省级教学名师，安徽省学术技术带头人，省高校拔尖人才。研究方向为生殖发育毒理学和肝脏毒理学。兼任中华预防医学学会自由基医学专委会副主委、中国毒理学会毒理学教育专委会副主委、中国环境诱变剂学会生物标志专委会常委、中华预防医学学会卫生毒理学分会常委、中国毒理学会免疫毒理学专委会常委、安徽省环境诱变剂学会理事长。主持国家自然科学基金重点项目1项、重大专项1项、面上项目6项，以通讯作者发表SCI论文120篇，2014~2018年连续5年入选中国高被引学者榜，获安徽省科学技术（自然科学）一等奖1项、二等奖2项、三等奖1项，中华医学奖2项、中华预防医学奖1项。

近年代表作

[1]Li R, Wang X, Wang B, Li J, Song Y, Luo B, Chen Y, Zhang C, Wang H, Xu D. Gestational 1-nitropyrene exposure causes fetal growth restriction through disturbing placental vascularity and proliferation. Chemosphere 2018; 213: 252-258.

[2]Chen YH, Tao FB, Xu DX. The Association between Pre-pregnancy Body Mass Index and Risk of Preterm Delivery in Chinese Population. Am J Epidemiol 2018; 187: 1123-1124.

[3]Li J, Wang H, Hao JH, Chen YH, Liu L, Yu Z, Fu L, Tao FB, Xu DX. Maternal serum lead level during pregnancy is positively correlated with risk of preterm birth in a Chinese population. Environ Pollut 2017; 227: 484-489.

[4]Wang B, Liu JJ, Wang Y, Fu L, Shen R, Yu Z, Wang H, Chen YH, Zhang C, Meng XH, Xu DX. Maternal Fenvalerate Exposure Induces Fetal Intrauterine Growth Restriction Through Disrupting Placental Thyroid Hormone Receptor Signaling. Toxicol Sci 2017; 157: 377-386.

[5]Chen YH, Hu XG, Zhou Y, Yu Z, Fu L, Zhang GB, Bo QL, Wang H, Zhang C, Xu DX. Obeticholic Acid Protects against Lipopolysaccharide-Induced Fetal Death and Intrauterine Growth Restriction through Its Anti-Inflammatory Activity. J Immunol 2016; 197: 4762-4770.

[6]Wang H, Hu YF, Hao JH, Chen YH, Wang Y, Zhu P, Zhang C, Xu YY, Tao FB, Xu DX. Maternal serum zinc concentration during pregnancy is inversely associated with risk of preterm birth in a Chinese population. J Nutr 2016; 146: 509-515.

[7]Bo QL, Chen YH, Yu Z, Fu L, Zhou Y, Zhang GB, Wang H, Zhang ZH, Xu DX. Rosiglitazone pretreatment protects against lipopolysaccharide- induced fetal demise through inhibiting placental inflammation. Mol Cell Endocrinol 2016; 423: 51-59.

[8]Xu S, Chen YH, Tan ZX, Xie DD, Zhang C, Xia MZ, Wang H, Zhao H, Xu DX, Yu DX. Vitamin D3 pretreatment alleviates renal oxidative stress in lipopolysaccharide-induced acute kidney injury. J Steroid BiochemMol Biol 2015; 152: 133-141.

[9]Chen YH, Fu L, Hao JH, Yu Z, Zhu P, Wang H, Xu YY, Zhang C, Tao FB, Xu DX. Maternal vitamin D deficiency during pregnancy elevates the risks of small for gestational age and low birth weight infants in Chinese population. J Clin Endocrinol Metab 2015; 100: 1912-1919.

[10]Liu XJ, Wang BW, Zhang C, Xia MZ, Chen YH, Hu CQ, Wang H, Chen X, Xu DX. Vitamin d deficiency attenuates high-fat diet-induced hyperin- sulinemia and hepatic lipid accumulation in male mice. Endocrinology 2015; 156: 2103-2113.

[11]Xia MZ, Liang YL, Wang H, Chen X, Huang YY, Zhang ZH, Chen YH, Zhang C, Zhao M, Xu DX, Song LH. Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells. J Pineal Res 2012; 53: 325-334.

[12]Ji YL, Wang H, Meng C, Zhao XF, Zhang C, Zhang Y, Zhao M, Chen YH, Meng XH, Xu DX. Melatonin alleviates cadmium-induced cellular stress and germ cell apoptosis in testes. J Pineal Res 2012; 52: 71-79.

[13]Wang H, Wang Q, Zhao XF, Liu P, Meng XH, Yu T, Ji YL, Zhang H, Zhang C, Zhang Y, Xu DX. Cypermethrin Exposure during Puberty Disrupts Testosterone Synthesis via Downregulating StAR in Mouse Testes. Arch Toxicol 2010; 84: 53-61.

[14]Lu JW, WangH, Ji YL, Zhang C, Ning H, Li XY, Zhang H, Duan ZH, Zhao L, Wei W, Xu DX. Differential effects of pyrrolidine dithiocarbamate on TNF-α- mediated liver injury in two different models of fulminant hepatitis. J Hepatol 2008; 48: 442-452.

[15]Xu DX, Wei W, Sun MF, Wu CY, Wang JP, Wei LZ, Zhou CF. Kupffer cells and ROS partially mediate LPS-induced down-regulation of nuclear receptor pregnane X receptor and its target gene CYP3Ain mouse liver. Free Radic Biol Med 2004; 37: 10-22.

主持科研项目

[1]国家自然科学基金重点项目，81630084，孕期维生素D缺乏与胎儿生长受限的关联及其机制研究，在研

[2]国家自然科学基金重大专项，91743105，孕期1-硝基芘暴露与胎儿宫内生长受限的关联及其毒理学机制，在研

[3]国家自然科学基金面上项目，81373495，Toll样受体4在对乙酰氨基酚肝损伤不同阶段肝细胞程序性坏死和再生中的作用，已结题

[4]国家自然科学基金面上项目，81172711，活性氧和一氧化氮介导的胎盘内质网应激在LPS致畸中的作用，已结题

[5]国家自然科学基金面上项目，30973544，ROS、PGs、NO和TNF-α在LPS调控肝细胞LXR-α及其靶基因中的作用，已结题

教授，博士生导师，省教学名师，省高校拔尖人才，省学术技术带头人后备人选。主要从事遗传（SHP-2酪氨酸磷酸酶、miRNA）与环境因素（重金属污染物及酒精滥用）对肿瘤发生发展的影响及机制研究。获美国NIH人才培养计划基金资助在Case Western Reserve University进修，随后三次去University of Kentucky做高级访问学者。现任安徽医科大学实验教学中心主任兼基础医学院副院长。中国病理生理学会理事及消化专业委员会副主任委员，中国实验动物学会理事，中国标准化委员会实验动物标准化委员，国家级试验示范中心联席会基础医学组副组长。主持国家自然科学基金课题7项，教育部博士点基金及省科技厅和教育厅科研教研项目12项。发表研究论文200余篇，其中在PNAS、Blood、 Cancer Res.、J. of Hepatology、 J . Mol .Cell Biol.、J.B.C.、Cancer letters、 Molecular Cancer等SCI期刊上发表50余篇。

近年代表作

[1]Chen D, Yu D, Wang X, Liu Y, He Y, Deng R, Jiang Y, Zhang F, Xu M, Li J, Luo J, Wang S*. Epithelial to mesenchymal transition is involved in ethanol promoted hepatocellular carcinoma cells metastasis and stemness. Mol Carcinog. 2018; 57:1358-1370. [IF= 4.185]

[2]Zhao H, Chen D, Cao R, Wang S, Yu D, Liu Y, Jiang Y, Xu M, Luo J, Wang S*. Alcohol consumption promotes colorectal carcinoma metastasis via a CCL5-induced and AMPK-pathway-mediated activation of autophagy. Scientific Reports. 2018; 8:8640. [IF= 4.259]

[3]Zhang Q, Li Y, Zhao R, Wang X, Fan C, Xu Y, Liu Y, Li J, Wang S*. The gain-of-function mutation E76K in SHP2 promotes CAC tumorigenesis and induces EMT via the Wnt/β-catenin signaling pathway. Mol Carcinog. 2018;57(5):619-628. [IF= 4.185]

[4]Xu M, Ren Z, Wang X, Comer A, Frank JA, Ke ZJ, Huang Y, Zhang Z, Shi X, Wang S*, Luo J*. ErbB2 and p38γ MAPK mediate alcohol-induced increase in breast cancer stem cells and metastasis. Mol Cancer. 2016; 15(1):52. [IF= 6.204]

[5]Xu M, Wang S, Qi Y, Chen L, Frank JA, Yang XH, Zhang Z, Shi X, Luo J. Role of MCP-1 in alcohol-induced aggressiveness of colorectal cancer cells. Mol Carcinog. 2016;55(5):1002-11. [IF= 4.185]

[6]Chen DL, Hu ZQ, Zheng XF, Wang XY, Xu YZ, Li WQ, Fang HS, Kan L, Wang SY*. EDAG-1 promotes proliferation and invasion of human thyroid cancer cells by activating MAPK/Erk and AKT signal pathways. Cancer Biol Ther. 2016; 17(4): 414-21. [IF= 3.294]

[7]Liu X, Zheng H, Li X, Wang S, Meyerson HJ, Yang W, Neel BG, Qu CK. Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies. Proc Natl Acad Sci USA. 2016; 113(4):984-9. [IF= 9.661]

[8]Ni F, Zhao H, Cui H, Wu Z, Chen L, Hu Z, Guo C, Liu Y, Chen Z, Wang X, Chen D, Wei H,Wang S*. MicroRNA-362-5p promotes tumor growth and metastasis by targeting CYLD in hepatocellular carcinoma. Cancer Lett. 2015; 356 (2): 809-18. [IF= 7.375]

[9]Yang P, Ni F, Deng RQ, Qiang G, Zhao H, Yang MZ, Wang XY, Xu YZ, Chen L, Chen DL, Chen ZJ, Kan LX, Wang SY*. MiR-362-5p promotes the malignancy of chronic myelocytic leukaemia via down-regulation of GADD45α. Mol Cancer. 2015;14(1):190. [IF= 7.004]

[10]Wang F, Yang JL, Yu KK, Xu M, Xu YZ, Chen L, Lu YM, Fang HS, Wang XY, Hu ZQ, Li FF, Kan L, Luo J, Wang SY*. Activation of the NF-κB pathway as a mechanism of alcohol enhanced progression and metastasis of human hepatocellular carcinoma. Mol Cancer. 2015; 14:10. [IF= 6.204]

[11]Wang S, Wang S, Yang L, Guo H, Kong X, Yuan L, Xing G, He F, Zhang L. ARF-mediated SUMOylation of Apak antagonizes ubiquitylation and promotes its nucleolar accumulation to inhibit 47S pre-rRNA synthesis.J Mol Cell Biol. 2015;7(2):154-67. [IF= 8.159]

[12]Sun JL, Chen DL, Hu ZQ, Xu YZ, Fang HS, Wang XY, Kan L, Wang SY*. Arsenite promotes intestinal tumor cell poliferation and invasion by stimulating epithelial-to-mesenchymal transition. Cancer Biol Ther. 2014; 15(10):1312-1319. [IF= 3.294]

[13]Yu K, Yang J, Wang F, Chen L, Lu Y, Luo J, Wang S*. Ethanol supports macrophage recruitment and reinforces invasion and migration of Lewis lung carcinoma. Alcohol Clin Exp Res. 2014; 38(10):2597-606. [IF= 3.28]

[14]Wang S*, Xu M, Li F, Wang X, Bower KA, Frank JA, Lu Y, Chen G, Zhang Z, Ke Z, Shi X, Luo J. Ethanol promotes mammary tumor growth and angiogenesis: the involvement of chemoattractant factor MCP-1.Breast Cancer Res Treat. 2012 Jun;133(3):1037-48.[IF= 4.32]

[15]Zhang Y, Chen L, Gao W, Hou X, Gu Y, Gui L, Huang D, Liu M, Ren C, Wang S *, Shen J. IL-17 neutralization significantly ameliorates hepatic granulomatous inflammation and liver damage in Schistosoma japonicum infected mice. Eur J Immunol. 2012 Jun; 42(6):1523-35. [IF= 4.179]

主持科研项目 

[1]国家自然科学基金面上项目，81772988，miR100-FZD8-β-catenin轴在环境因素促发原发性肝癌过程中的关键作用及机制，2018.1-2021.12， 55万，在研，主持

[2]国家自然科学基金面上项目，81572749，MiR-100失活在重金属污染物砷协同激活突变Ptpn11促发肺癌中的关键作用及机制，2016.1-2019.12，57万，在研。主持

[3]国家自然科学基金面上项目，81272258，激活突变SHP-2酪氨酸磷酸酶促进重金属污染物诱发的小鼠肿瘤发生及其分子机制探讨，2013.01-2016.12，65 万，结题。主持

[4]国家自然科学基金面上项目，81072663，基于癌基因SHP-2（PTPN11) 酪氨酸磷酸酶高效、特异性抑制物的筛选与鉴定，2010.01-2013.12， 38 万，结题。主持

[5]国家自然科学基金面上项目，30873046, 激活突变SHP2（PTPN11）磷酸酶对白血病细胞恶性生物学行为的影响及分子机制探讨，2009.1-2011.12，30 万，结题。主持