获吴阶平-保罗·杨森奖，中国杰出神经内科医师—学术成就奖。曾任安徽医科大学副校长、精神卫生与心理科学院院长。现任安徽省转化医学研究院院长，安徽医科大学第一附属医院神经内科主任，“认知与神经精神疾病”安徽省重点实验室主任，安徽省“神经精神疾病与心理健康”协同创新中心主任。主持包括国家自然科学基金重大项目，重大研究计划，联合重点项目等10项。课题组发挥神经病学、精神病学、心理学及脑科学交叉合作的团队优势，聚焦相关疾病的神经病理机制、神经调控机制和转化医学研究。成果发表在JAMA、Nat Genet、Nat Neurosci、Nat Mental Health、Mol Psychiatry、PNAS、Brain Stimul等期刊。获安徽省科技进步一、二等奖和中华医学科技一等奖等。

国家级课题

1. 多元矛盾纠纷成因分析及疏导技术研究与应用示范—矛盾纠纷心理干预与康复服务关键技术（2021YFC3300500）国家重点研发计划，2021.12-2024.11，895万，进行中。

2. 血管性认知障碍的生物标志物谱系评价体系和智能诊疗研究—血管性认知障碍纵向队列建设及早期干预研究（2021YFC2500101）国家重点研发计划，2021.12-2024.11，250万，进行中。

3. 疫情相关焦虑障碍风险预测模型建立及多模态诊疗新方案的研究（82090034）国家自然科学基金重大项目，2021.01-2025.12, 472.5，进行中。

4. 难治性抑郁症患者抑郁性沉思的神经环路机制及其TMS干预研究（31970979）国家自然科学基金，2020.01-2023.12, 58万，进行中。

5. 慢性脑小血管病发病机制及临床诊治新策略—脑小血管病的临床评估体系（2016YFC1300604） 国家重点研发计划，2016.09-2020.12，194万，已结题。

6. 催产素及其受体基因在精神分裂症共情障碍的神经机制研究 (31571149）国家自然科学基金，2016.01-2019.12, 76.8万，已结题。

7. 自闭症共情障碍神经环路的基因影像学研究 (91432301)，国家自然科学基金重大研究计划-集成项目，2015.01-2018.12，280万，已结题。

8. 自闭症患者情绪障碍及其神经环路机制的研究(91232717)，国家自然科学基金 重大研究计划培育，2013.01-2015.12，70万，已结题。

9. 幻听的脑网络神经基础及其rTMS治疗的机制研究(81171273)，国家自然科学基金，2012.01-2015.12，62万，已结题。

10. 睡眠脑功能及其机制研究--睡眠异常的遗传学机制(2015CB856405)，“973计划”子课题，2014.1-2016.12，125万，已结题。

11. 中国语言相关脑功能区与语言障碍的关键科学问题研究--语言区临床保护、康复相关的基础理论问题和转化医学研究(2012CB720704)，“973计划”子课题，2014.1-2016.12，92.16万，已结题。

12. 精神分裂症的脑网络研究(2011CB707805），“973计划”子课题，2011.01.01-2015. 12. 31，100万，已结题。

13. 注意网络及其神经基础的研究(30870766)，国家自然科学基金，2009.01-2011.12，35万，顺利结题。

14. 社会认知的神经机制研究(30670706)，国家自然科学基金, 2007.01-2009.12，30万，顺利结题。

15. 情绪认知的特异性神经机制(30370479)，国家自然科学基金，2004.01-2006.12，21万，顺利结题。

16. 脑血管病流行病学横断面调查、示范社区高危人群早期筛查干预技术及临床研究公共平台建立研究(2011BAI08B01)，“十二五”国家科技支撑计划课题，2012.04.08-2013.12.31，13万，顺利结题。

17. 癌症病人心理问题的早期识别和预警、癌症后抑郁干预研究(2009BAI77B06)，“十一五”国家科技支撑计划课题，2011.1.1-2013.12.12，19.98万，顺利完成。

18. 特征捆绑和不变性知觉的脑认知功能成像(2005CB22800)，“973计划”子课题，2006.01-2010.11，30万，顺利结题。

19. MCI诊断和干预研究(2006BAI02B01)，“十一五”国家科技支撑计划课题，2007-2009，3.5万，顺利结题。

20. 国家教育部归国留学人员科研启动基金3万((2003)14)

1.  Chen HS, Cui Y, Zhou ZH, Dai YJ, Li GH, Peng ZL, Zhang Y,..., Wang K, Wang DL, Wang YL; ARAIS Investigators. Effect of Argatroban Plus Intravenous Alteplase vs Intravenous Alteplase Alone on Neurologic Function in Patients With Acute Ischemic Stroke: The ARAIS Randomized Clinical Trial. JAMA. 2023  9:e230550.

2. Zhang L#, Li Q, Du Y, Gao Y, Bai T, Ji GJ, Tian Y*, Wang K* (corresponding author). Effect of high- definition transcranial direct current stimulation on improving depression and modulating functional activity in emotion-related cortical-subcortical regions in bipolar depression. J Affect Disord. 2023  15;323:570-580.

3. Li D#, Zhang L, Bai T, Qiu B, Zhu C*, Wang K* (corresponding author). Oxytocin-Receptor Gene Modulates Reward-Network Connection and Relationship with Empathy Performance. Psychol Res Behav Manag. 2023  7;16:85-94.

4. Xie X#, Hu P, Tian Y, Qiu B, Wang K* (co-corresponding author), Bai T*. Abnormal resting-state function within language network and its improvement among post-stroke aphasia. Behav Brain Res.2023 11;443:114344.

5.  Li N, Li C, Xie X, Liu G, Wang K, Zhang W, Fan J. Impairment of attention network function in posterior circulation ischemia-evidence from the Attention Network Test. Front Hum Neurosci. 2023  6;16:1001500.

6. Xu J#, Li W#, Bai T#, Li J, Zhang J, Hu Q, Wang J*, Tian Y*, Wang K. Volume of hippocampus-amygdala transition area predicts outcomes of electroconvulsive therapy in major depressive disorder: high accuracy validated in two independent cohorts. Psychol Med. 2022 23:1-10.

7. Ding YD, Chen X, Chen ZB, Li L, Li XY, Castellanos FX, Bai TJ,..,Wang K,..., Zou CJ, Zuo XN, Yan CG, Guo WB. Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder. Transl Psychiatry. 2022  6;12(1):236.

8. Xiao G#, Wu Y#, Yan Y#, Gao L, Geng Z, Qiu B, Zhou S, Ji G, Wu X*, Hu P*, Wang K* (corresponding author). Optimized Magnetic Stimulation Induced Hypoconnectivity Within the Executive Control Network Yields Cognition Improvements in Alzheimer's Patients. Front Aging Neurosci. 2022  15;14:847223.

9. Wang L#, Li Q#, Wu Y, Ji GJ, Wu X, Xiao G, Qiu B, Hu P, Chen X*, He K*, Wang K* (corresponding author). Intermittent theta burst stimulation improved visual-spatial working memory in treatment-resistant schizophrenia: A pilot study.  J Psychiatr Res. 2022 23;149:44-53.

10. Wu Y#, Ji Y#, Bai T, Wei Q, Zu M, Guo Y, Lv H, Zhang A, Qiu B, Wang K* (co-corresponding author), Tian Y*. Nodal degree changes induced by electroconvulsive therapy in major depressive disorder: Evidence in two independent cohorts. J Affect Disord. 2022 21:S0165-0327(22)00285-3.

11. Zhao Q#, Guo Q, Shi Z, Cai Z, Zhang L, Li D, Chen Q, Du J, Wang K* (co-corresponding author), Zhang L*. Promoting gaze toward the eyes of emotional faces in individuals with high autistic traits using group cognitive behavioral therapy: An eye-tracking study. J Affect Disord. 2022 15;306:115-123.

12. Zhu C#, Fu Z#, Chen L, Yu F, Zhang J, Zhang Y, Ai H, Chen L, Sui P, Wu Q, Luo Y, Xu P*, Wang K* (corresponding author). Multi-modality connectome-based predictive modeling of individualized compulsions in obsessive-compulsive disorder. J Affect Disord. 2022  31:S0165-0327(22)00646-2.

13.  Li Y, Li Y, Wei Q, Bai T, Wang K, Wang J*, Tian Y*. Mapping intrinsic functional network topological architecture in major depression disorder after electroconvulsive therapy. J Affect Disord. 2022  18;311:103-109.

14. Zhang T#, Xie X#, Li Q#, Zhang L, Chen Y, Ji GJ, Hou Q, Li T, Zhu C*, Tian Y*, Wang K. Hypogyrification in Generalized Anxiety Disorder and Associated with Insomnia Symptoms. Nat Sci Sleep. 2022  25;14:1009-1019.

15. Yu F#, Huang Y#, Chen T#, Wang X, Guo Y, Fang Y, He K, Zhu C, Wang K* (co-corresponding author), Zhang L*. Repetitive transcranial magnetic stimulation promotes response inhibition in patients with major depression during the stop-signal task. J Psychiatr Res. 2022  13;151:427-438.

16. Zhang L#*, Xuan R, Chen Q, Zhao Q, Shi Z, Du J, Zhu C, Yu F, Ji G, Wang K* (co-corresponding author). High-definition transcranial direct current stimulation modulates eye gaze on emotional faces in college students with alexithymia: An eye-tracking study. Prog Neuropsychopharmacol Biol Psychiatry. 2022 29:110521.

17. Huang YY#, Chen SD, Leng XY, Kuo K, Wang ZT, Cui M, Tan L, Wang K* (co-corresponding author), Dong Q*, Yu JT*. Post-Stroke Cognitive Impairment: Epidemiology, Risk Factors, and Management. J Alzheimers Dis. 2022  9.

18. Spagna A#*, Wang J#, Rosario IE#, Zhang L, Zu M, Wang K* (co-corresponding author), Tian Y*. Cognitive Considerations in Major Depression: Evaluating the Effects of Pharmacotherapy and ECT on  Mood and  Executive Control Deficits. Brain Sci. 2022  4;12(3):350.

19. Xie X#, Zhang T#, Bai T, Chen C, Ji GJ, Tian Y, Yang J,  Wang K* (corresponding author). Resting-State Neural-Activity Alterations in Subacute Aphasia after Stroke. Brain Sci. 2022  22;12(5):678.

20. Pang Y#, Wei Q, Zhao S, Li N, Li Z, Lu F, Pang J, Zhang R, Wang K, Chu C*, Tian Y*, Wang J*. Enhanced default mode network functional connectivity links with electroconvulsive therapy response in major depressive disorder. J Affect Disord. 2022  16;306:47-54.

21. Zhu RL#, Ouyang C, Ma RL, Wang K* (corresponding author). Obstructive sleep apnea is associated with cognitive impairment in minor ischemic stroke. Sleep Breath. 2022  19.

22. Tu H#, Gong G#, Zhang S, Fu Y, Wang T, Chu Q, Hu S, Wang K, Zhu C*, Fan Y*. The association between illness perception and quality of life among Chinese adults with epilepsy: The mediating role of coping style. Epilepsy Behav. 2022 ;130:108677.

23. Cao R#, Ma R#, Wang K* (co-corresponding author), Hu P*. Association Between Dopaminergic Medications and the Evolution of REM Sleep Behavior Disorder in Parkinson's Disease. Front Neurol. 2022  10;13:880583.

24. Zhang Q#, Li X#, Liu X, Liu S, Zhang M, Liu Y, Zhu C*, Wang K. The Effect of Non-Invasive Brain Stimulation on the Downregulation of Negative Emotions: A Meta-Analysis. Brain Sci. 2022  15;12(6):786.

25. Han J#, Chen C#, Zheng S, Yan X, Wang C, Wang K* (co-corresponding author), Hu Y*. High-Definition Transcranial Direct Current Stimulation of the Dorsolateral Prefrontal Cortex Modulates the Electroencephalography Rhythmic Activity of Parietal Occipital Lobe in Patients With Chronic Disorders of Consciousness. Front Hum Neurosci. 2022  27;16:889023.

26. Wu Y#, Wu X#, Gao L, Yan Y, Geng Z, Zhou S, Zhu W, Tian Y, Yu Y, Wei L*,  Wang K* (corresponding author). Abnormal Functional Connectivity of Thalamic Subdivisions in Alzheimer's Disease: A Functional Magnetic Resonance Imaging Study. Neuroscience. 2022 8;496:73-82.

27. Li Y, Yu X, Ma Y, Su J, Li Y, Zhu S, Bai T, Wei Q, Becker B, Ding Z, Wang K, Tian Y*, Wang J*. Neural signatures of default mode network in major depression disorder after electroconvulsive therapy. Cereb Cortex. 2022  10:bhac311.

28. Chen L#, Xu Z#, Zhang C, Ji Y, Huang X, Yang W, Zhou Z, Wang S, Wang K, Luo B, Wang J*. Post-ASPECTS based on hyperdensity in NCCT immediately after thrombectomy is an ultra-early predictor of hemorrhagic transformation and prognosis. Front Neurol. 2022 10;13:887277.

29.  Han J#, Chen C#, Zheng S, Zhou T, Hu S, Yan X, Wang C, Wang K, Hu Y*. Functional Connectivity Increases in Response to High-Definition Transcranial Direct Current Stimulation in Patients with Chronic Disorder of Consciousness. Brain Sci. 2022  18;12(8):1095.

30. Guo Y#, Lv X#, Zhang J, Li C, Wei L, Zhou N, Xu J*, Tian Y*, Wang K . Gray matter atrophy and corresponding impairments in connectivity in patients with anti-N- methyl-D-aspartate receptor encephalitis. Brain Imaging Behav. 2022  23.

31. Zhang L#, Li Z, Wu Y, Yu Y, Ji GJ, Tian Y*, Wang K* (corresponding author). Frontothalamic Circuit Abnormalities in Patients With Bipolar Depression and Suicide Attempts. J Clin Psychiatry. 2022 5;  83(6):21m14185.

32. Sun J#, Du R, Zhang B, Hua Q, Wang Y, Zhang Y, Ji GJ*, He K*, Wang K* (corresponding author). Minimal scanning duration for producing individualized repetitive transcranial magnetic stimulation targets. Brain Imaging Behav. 2022  1.

33. Wang Y#, Zhou Y, Zhang X, Wang K, Chen X*, Cheng H*. Orienting network impairment of attention in patients with mild traumatic brain injury. Behav Brain Res. 2022  27;437:114133.

34. Zhang L#, Du J#, Chen T, Sheng R, Ma J, Ji G, Yu F, Ye J, Li D, Li Z, Zhu C*, Wang K. Longitudinal changes in mental health among medical students in China during the COVID-19 epidemic: depression, anxiety and stress at 1-year follow-up. Psychol Health Med. 2022  27:1-11.

35. Huang Y#, Zhu C#, Feng Y, Ji Y, Song J, Wang K* (co-corresponding author), Yu F*. Comparison of three machine learning models to predict suicidal ideation and depression among Chinese adolescents: A cross-sectional study. J Affect Disord. 2022  16;319:221-228.

36. Du R#, Zhou Q#, Hu T#, Sun J, Hua Q, Wang Y, Zhang Y, He K, Tian Y, Ji GJ*, Wang K* (corresponding author). A landmark-based approach to locate symptom-specific transcranial magnetic stimulation targets of depression. Front Psychol. 2022  2;13:919944.

37. Li M#, Li X, Zhu W, Zhu J, Wang H, Gao Z, Wu X, Zhou S,Wang K* (co-corresponding author), Yu Y*. The contribution of the left precuneus to emotion memory in migraine without aura patients. Front Neurosci. 2022  18;16:905942.

38. Yu F#, Fang H#, Zhang J, Wang Z, Ai H, Kwok VPY, Fang Y, Guo Y, Wang X, Zhu C, Luo Y, Xu P*, Wang K* (corresponding author). Individualized prediction of consummatory anhedonia from functional connectome in major depressive disorder. Depress Anxiety. 2022  3.

39. Ji GJ#, Zalesky A, Wang Y, He K, Wang L, Du R, Sun J, Bai T, Chen X, Tian Y, Zhu C, Wang K* (corresponding author). Linking Personalized Brain Atrophy to Schizophrenia Network and Treatment Response. Schizophr Bull. 2022  1:sbac162.

40. Hua Q#, Zhang Y#, Li Q#, Gao X, Du R, Wang Y, Zhou Q, Zhang T, Sun J, Zhang L, Ji GJ*, Wang K* (corresponding author). Efficacy of twice-daily high-frequency repetitive transcranial magnetic stimulation on associative memory. Front Hum Neurosci. 2022 12;16:973298.

41. Zhang L#, Li Q, Du Y, Gao Y, Bai T, Ji GJ, Tian Y, Wang K* (corresponding author). Effect of high- definition transcranial direct current stimulation on improving depression and modulating functional activity in emotion-related cortical-subcortical regions in bipolar depression. J Affect Disord. 2022  8:S0165-0327(22)01367-2.

42. Xie X#, Hu P, Tian Y, Wang K* (co-corresponding author), Bai T*. Transcranial alternating current stimulation enhances speech comprehension in chronic post-stroke aphasia patients: A single-blind sham-controlled study. Brain Stimul. 2022  6;15(6):1538-1540.

43. Ji GJ#*, Li J, Liao W, Wang Y, Zhang L, Bai T, Zhang T, Xie W, He K, Zhu C, Dukart J, Baeken C, Tian Y*,  Wang K* (corresponding author). Neuroplasticity-Related Genes and Dopamine Receptors Associated with Regional Cortical Thickness Increase Following Electroconvulsive Therapy for Major Depressive Disorder. Mol Neurobiol. 2022  5.

44. Liu Y#, Cao S#, Du B, Zhang J, Chen C, Hu P, Tian Y, Wang K, Ji GJ, Wei Q*. Different Dynamic Nodal Properties Contribute to Cognitive Impairment in Patients with White Matter Hyperintensities. Brain Sci. 2022  10;12(11):1527.

45.  Zhu C#, Zhang T, Li Q, Chen X, Wang K* (corresponding author). Depression and Anxiety During the COVID-19 Pandemic: Epidemiology, Mechanism, and Treatment. Neurosci Bull. 2022  21:1–10.

46. Yu Y#, Chen Y#, Wu Y, Bai T, Wei Q, Ji Y, Zhang T, Li C, Zhang A, Wang K* (co-corresponding author), Tian Y*. The Common Neural Mechanism of Somatic Symptoms of Depression and Anxiety Disorders: A Resting-State Functional Magnetic Resonance Imaging Study. Neuropsychobiology. 2022 16:1-10.

47. Chang X, Wang K, Wang Y, Tu H, Gong G, Zhang H. Medication Literacy in Chinese Patients with Stroke and Associated Factors: A Cross-Sectional Study. Int J Environ Res Public Health. 2022  29;20(1):620.

48. Li G, Zhu J, Wu X, Liu T, Hu P*, Tian Y*, Wang K* (corresponding author). Baseline free water within the visual processing system predicts future psychosis in Parkinson's disease. Eur J Neurol. 2022  30.

Chen C#, Han J, Zheng S, Zhang X, Sun H, Zhou T, Hu S, Yan X, Wang C, Wang K* (co-corresponding author), Hu Y*. Dynamic Changes of Brain Activity in Different Responsive Groups of Patients with Prolonged Disorders of Consciousness. Brain Sci. 2022 20;13(1):5.

“抑郁症的认知脑网络机制与干预研究及其临床应用”获得2019年安徽省科学技术奖一等奖 排名第1

“老年性痴呆早期预警、诊断与干预研究”获得2014年江苏省科技进步一等奖 排名第3

“精神疾病认知障碍的发生机制与临床研究”获得2011年中华医学科技奖一等奖 排名第3

“情绪认知能力的测量、情绪加工的特异性神经机制研究及其临床应用”获得2010年安徽省科学技术奖二等奖 排名第1